Amebiasis, caused by Entamoeba histolytica, primarily spreads through contaminated food and water. Currently, there is no vaccine available to prevent amebiasis, but research is ongoing to develop one. Preventative measures focus on maintaining proper hygiene, drinking clean water, and consuming properly cooked food. For treatment, medications likenizonide (nitazoxanide) are commonly prescribed to combat the infection effectively. Nizonide targets protozoan infections and is particularly useful in intestinal cases. Efforts to improve sanitation and public health awareness remain crucial in areas where amebiasis is prevalent, as these measures significantly reduce transmission and the overall disease burden.