Phenotypic screens

Phenotypic screens in neurodegeneration are being facilitated by advances in screening models all the way from primitive organisms such as yeast to complex 3D cell models. The outcome of a screen is critically dependent on the design of the assay, the nature of the screening collection, the concentrations of the test molecules, and an appropriate triage effort to confirm the hits. Neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and frontotemporal dementia (FTD) are debilitating disorders, and there are currently no disease-modifying therapies available to patients.