Ceftriaxone Injection should not be administered to individuals with known hypersensitivity to ceftriaxone, other cephalosporins, or any component of the formulation, as severe allergic reactions may occur. It is contraindicated in premature infants and neonates (≤28 days) with jaundice, hypoalbuminemia, or those receiving calcium-containing IV solutions due to the risk of fatal precipitates in the lungs and kidneys. Patients with a history of anaphylaxis to penicillin should avoid ceftriaxone injection unless desensitized. Those with gallbladder disease or a history of Ceftriaxone Injection-related sludge should use it cautiously, as it may exacerbate these conditions. Always consult a healthcare provider.